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Synthetic organic chemists typically default to introducing hazardous chemistry and in particular, fluorine, into the early stages of a synthetic process. The cost of the early fluorine introduction can represent a significant cost to the final API as yield losses downstream and potential for de-fluorination impurities through further processing can magnify those early costs exponentially. Thus, customers search for the least expensive, but also most reliable entry point in the synthesis for fluorine introduction.

In addition to fluorination, hazardous reactions such as nitration and high-pressure hydrogenation are often sought for early chemical steps in an API synthesis.

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